News

Say goodbye to jet lag

Say goodbye to jet lag

Photo: clipart.com

LONDON (Reuters) – Scientists have found a genetic mechanism in mice that hampers their body clock’s ability to adjust to changes in patterns of light and dark, and say their results could someday lead to the development of drugs to combat jet lag.

Researchers from Britain’s Oxford University and from the Swiss drug firm Roche used mice to analyze patterns of genes in an area of the brain called the suprachiasmatic nuclei (SCN) – which in mammals pulls every cell in the body into the same biological rhythm.

They found that one molecule, called SIK1, is key to how the mice responded to changes in light cycles.

When the scientists blocked the activity of SIK1, the mice recovered faster from disturbances in their daily light and dark cycle that had been designed to induce a form of mouse jet lag.

If the corresponding mechanism can be found and similarly blocked in humans, jet lag may become a thing of the past, the researchers said in their study, published online in the journal Cell on Thursday.

“We’re still several years away from a cure for jet lag, but understanding the mechanisms that generate and regulate our circadian clock gives us targets to develop drugs to help bring our bodies in tune with the solar cycle,” said Russell Foster, director of Oxford’s sleep and circadian neuroscience institute.

He said such drugs could also have broader potential value, including for people with mental illnesses where sleep disturbances are common.

Recent Headlines

in Music

This week’s top country tracks

Fresh
frankieballard

LISTEN: This week's top country tracks, according to the latest Billboard chart.

in Black Friday, Entertainment

‘Frozen’ tops Barbie as top girls’ holiday pick

frozen

The results marked the first time in 11 years that Barbie hasn't held the No. 1 spot in the annual toy survey.

in Black Friday, Viral Videos

Black Friday facts that will make you think twice

22-overlay2

Before you wait in line for doorbuster deals, check out these Black Friday facts.

in Trending, Viral Videos

TODAY’S MUST SEE: ‘Friends of the Galaxy’ mashup

24-overlay2

If "Guardians of the Galaxy" was set to the "Friends" theme.

in Entertainment

Today in entertainment history: Nov. 28

willienelson

A look at the Hollywood headlines that went down in history.